The Perro de Presa Canario is a Molosser type dog from the Canary Islands. This large breed was originally bred as a multi-purpose farm dog, being used as a cattle drover and guard dog. The name means the "Canarian Dog of Prey" and is sometimes simply called "Presa."

The breed is originally from the Canary Islands in the 1700s, notably Gran Canaria. Its exact ancestry is unknown, but enthusiasts believe that the Perro de Bardino Majorero, an established farm dog from the Canary Islands, was crossed with the Mastiff and Old-Style Bulldog brought from Europe to the Islands by visitors and colonists, creating the foundation for the modern Presa Canario. A number of Spanish breeds such as the Perro de Ganado Majorero, Presa Español, and Alano Español may have contributed to the development of the Presa Canario.

Presa type guard and catch dogs are mentioned in historical documents of the 16th and 17th centuries. It is believed that the Perro de Presa Canario was created during the 18th century for the purpose of property and flock guarding as well as the holding and driving of livestock. The breed was also used for dog fighting, a tradition the English settlers transplanted along with their Mastiff and Bulldog breeds. Canary Islanders consider these fights "honor fights" and not the sole purpose of the animal. They were used as guard dogs, and less often as farm dogs. Presa type dogs were referred to as the "perro de la tierra" or "dog of the land."

The breed became nearly extinct after dog fighting was outlawed in the 1940s, but the breed was revived in the 1970s with the help of several crosses by various breeders. This period is generally known as the reconstruction of the breed, with atypical specimens becoming less common.